LABRAINS developed an innovative product and conducted clinical research

LABRAINS developed an innovative product and conducted clinical research

LABRAINS, a company of natural dermocosmetics produced in Latvia, between November 2021 and January 2022, has performed the development of a new product, which after tests was named Dermatreat regenerating cream, and conducted a clinical study for the improvement of the skin condition and quality of life for patients with dermatitis symptoms. 43 people in different age groups participated in the study and it was carried out in Riga, Latvia, under the supervision of dermatologist Dr. Dina Mihailova. The study has been registered in the ISRCTN registry as per the requirements set out by the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) and International Committee of Medical Journal Editors (ICMJE) guidelines: ISRCTN52512550.

The aim of the study was to test the effectiveness of a two-formulation skincare routine for combined skin developed using a delicate storage and lipid regeneration layer system to promote balanced skin cell interactions and reduce homeostasis disturbances in the form of skin barrier dysfunction or inflammation.

The study included two developed products – Product No 1 (currently available on sale under the name Oil-to-milk facial cleanser and Product No 2 (currently available on sale under the name Dermatreat regenerating cream

Oil-to-milk facial cleanser was used to gently cleanse the face and remove all impurities (make-up, pollution particles) without causing adverse effects on the natural pH system and the protective barrier of the skin. This product is formulated with only naturally derived ingredients. Whereas Dermatreat regenerating cream was an O/W (oi in water) cream base designed for dermatitis-affected skin and consisting of ingredients of natural origin in accordance with European Parliament and Council Regulation (EC) No. 1223/2009 on cosmetic products. The allergenic potential of the substances included in the composition of this cosmetic product has been carefully evaluated in order to minimise possible allergic skin reactions. The cream was specifically developed for the relief of symptoms associated with atopic dermatitis. The composition of the active ingredients in the cream, which consists of ceramide NP, magnesium carboxymethyl-beta-glucan, hydrolyzed jojoba esters, betaine and Avena sativa (Oat) kernel extract, has been found to have a protective and healing activity on the skin (improving the skin barrier, maintaining skin moisture, reducing transepidermal water loss), the efficiency of which has been tested by the manufacturers of the ingredients.

Atopic dermatitis is a chronic inflammatory skin disease and there is no simple cure for it. However, thorough skin care can help control and alleviate everyday symptoms such as very dry, rough, irritated and red skin. A common characteristic of atopic dermatitis is an impaired skin barrier, resulting in increased transepidermal water loss that makes the skin dry and itchy. The study of skincare routines and their possible effectiveness in reducing the symptoms of atopic dermatitis is a substantive topic nowadays, while the research itself shows that the symptoms of atopic dermatitis occur in 2.4% of the population around the globe, with a specific prevalence in some countries, in Eastern and Northern Europe in particular. Atopic dermatitis significantly affects the quality of life of patients, and a large proportion of patients experience persistent itching, leading to continuous mental discomfort as well as a decrease in self-esteem, causing overall negative impact on quality of life.

However, majority of even natural skincare products that aim to alleviate the symptoms of atopic dermatitis are formulated using traditional and typically irritating preservative systems or antibacterial agents like benzyl alcohol, benzoic acid and its sodium salts, glyceryl caprylate, etc. Although being effective systems for maintaining the product, they often become a problem or harm to the user – causing loss of microbial diversity and discomfort due to irritation.

The most significant reduction of symptoms in the dimension of skin sensations was observed in the burning/heat sensation and in the dimension of visible skin changes – the reduction of the dilated vascular network. The results of the study can be interpreted as indicating the beneficial effects of using nature-based skincare products in case of atopic dermatitis. As it is evidenced also in study reports, the use of products of natural origins demonstrates clinical improvements in the overall appearance of the skin in dermatitis symptoms, and moreover, the natural regimen outperforms synthetic products at all levels of disease severity.

The development of the products implemented during the tests have been developed under the financial support of the Latvian State Competency Centre for the development of the natural preservative system in the Project Nr., VMKC.

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